Proton pump inhibitors (PPIs) are the most prescribed drugs in the United States. Americans spend more than $10 billion a year on these drugs, which include omeprazole, lansoprazole, rabeprazole and esomeprazole, designed to treat acid reflux and helicobacter pylori (H. pylori) infections. Now, after the drugs have been on the market for 25 years—the last 16 years of which they have been available without a prescription—some doctors and researchers are questioning whether protracted use of PPIs comes with long-term side effects, including the possibility of an increased cancer risk.
https://www.cancercenter.com/community/blog/2019/06/long-term-use-acid-reflux-drugs-cancer
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